Author

Changzheng Du

Beijing Tsinghua Chang Gung HospitalORCID 0000-0001-9016-4401Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:DNA methylation· 3 Research Focus:cancer & tumor microenvironment· 2 Approach:deep learning· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

Kun SuniD· 4 shared Mengqi YangiD· 4 shared Wanqiu WangiD· 4 shared Fanglei Gong· 3 shared Yunyun AniD· 3 shared Zhenyu Zhang· 3 shared Bianbian Tang· 2 shared Huizhen Lin· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

Kun SunORCID

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4 papers

Recent·Most cited

Cancer BiologyAdvanced SciencePeer-reviewedJan 22, 2026

Cancer-like fragmentomic characteristics of somatic variants in cell-free DNA

Zhenyu Zhang, Yunyun An, Mengqi Yang…·Kun Sun

This study identifies cancer-like fragmentomic traits in somatic variants of cfDNA, enabling cancer diagnosis through integrative genomic and fragmentomic analysis using AI models.

1 citation

humanwhole-genome sequencing

𝕏 PostBluesky

Cancer BiologybioRxivPreprintJul 10, 2025

Cell-free DNA fragmentomic characteristics in transposon elements inform molecular regulators and enhance cancer diagnosis

Fanglei Gong, Yuqi Pan, Huizhen Lin…·Kun Sun

This study identifies cfDNA fragmentomic features in transposon elements as biomarkers for cancer diagnosis, showing improved performance over genome-wide measurements.

DOI 10.1101/2025.07.10.664250

humanmouse

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Cancer BiologyScientific ReportsPeer-reviewedMar 12, 2025

Proteasome inhibition induces DNA methylation alteration by attenuating the synthesis of DNA methyltransferase 1 and 3B in colorectal cancer

Wenwen Zhou, Yuling Sheng, Dingxue Hu…·Changzheng Du

This study shows proteasome inhibition alters DNA methylation in colorectal cancer by reducing DNMT1 and DNMT3B synthesis via AKT/mTOR inactivation.

1 citation

humanDNA methylation

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Cancer BiologybioRxivPreprintDec 25, 2024

Candida albicans drives colorectal cancer progression by inducing hypoxia signaling

Wanqiu Wang, Mengqi Yang, Fanglei Gong…·Kun Sun

This study shows Candida albicans promotes colorectal cancer by activating hypoxia signaling through EGFR/TLR2 pathways.

3 citations

humanproteomics

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