Y. Chadani

The ABCF proteins in Escherichia coli individually alleviate nascent peptide-induced noncanonical translations.

This study identifies how ABCF proteins in E. coli alleviate noncanonical translations caused by specific nascent peptide sequences.

A method to enrich polypeptidyl-tRNAs to capture snapshots of translation in the cell

This paper introduces PETEOS, a method to enrich polypeptidyl-tRNAs for analysis of nascent proteins, and demonstrates its application in identifying proteins and observing translational responses to stress.

Nascent peptide-induced translation discontinuation in eukaryotes impacts biased amino acid usage in proteomes

The paper shows that nascent peptides with consecutive D/E residues can cause translation discontinuation in eukaryotes, leading to biased amino acid usage in proteomes.

Nascent polypeptide within the exit tunnel ensures continuous translation elongation by stabilizing the translating ribosome

The paper identifies nascent polypeptides as stabilizers of the translating ribosome, preventing elongation abortion by counteracting intrinsic ribosome destabilization sequences.

Escherichia coli small heat shock protein IbpA is an aggregation-sensor that self-regulates its own expression at a translational level

The paper shows IbpA, an Escherichia coli small heat shock protein, self-regulates its expression by sensing protein aggregation and relieving translational repression when aggregated.