H. Taguchi

Seesaw protein: Design of a protein that adopts interconvertible alternative functional conformations.

This paper designs a protein that can switch between two functional conformations, showing that such behavior can be controlled by mutations and ligands.

A beta-Galactosidase acting on unique galactosides: the structure and function of a beta-1,2-galactosidase from Bacteroides xylanisolvens, an intestinal bacterium

This study identifies a beta-galactosidase from Bacteroides xylanisolvens that hydrolyzes beta-1,2-galactooligosaccharides, revealing its unique substrate specificity through structural and biochemical analysis.

Pronounced expression of extracellular matrix proteoglycans regulated by Wnt pathway underlies the parallel evolution of lip hypertrophy in East African cichlids

The study identifies shared molecular mechanisms in hypertrophied lips of East African cichlids, linking Wnt pathway activation and extracellular matrix proteoglycan expression across different species.

Extensive distribution of β-1,2-glucanases: finding of new glycoside hydrolase families of β-1,2-glucanases

The paper identifies three new glycoside hydrolase families of β-1,2-glucanases and reveals their functional and structural relationships within a superfamily.

Functional and structural analysis of a cyclization domain in a cyclic beta-1,2-glucan synthase

The paper functionally and structurally analyzes the cyclization domain of a cyclic β-1,2-glucan synthase, revealing it produces cyclic β-1,2-glucans through transglycosylation without hydrolysis and proposes it belongs to a new glycoside hydrolase family.

The ABCF proteins in Escherichia coli individually alleviate nascent peptide-induced noncanonical translations.

This study identifies how ABCF proteins in E. coli alleviate noncanonical translations caused by specific nascent peptide sequences.

Reconstitution of C9orf72 (GGGGCC) repeat-associated non-AUG translation with purified components.

This study reconstitutes G4C2 repeat-associated non-AUG translation using purified human factors and identifies key features of the process.

Self-regulatory function of bacterial small heat shock protein IbpA through mRNA binding is conferred by a conserved arginine

This study identifies a conserved arginine residue in IbpA that mediates its self-repression of translation via mRNA binding, while preserving its chaperone activity.

A method to enrich polypeptidyl-tRNAs to capture snapshots of translation in the cell

This paper introduces PETEOS, a method to enrich polypeptidyl-tRNAs for analysis of nascent proteins, and demonstrates its application in identifying proteins and observing translational responses to stress.

Nascent peptide-induced translation discontinuation in eukaryotes impacts biased amino acid usage in proteomes

The paper shows that nascent peptides with consecutive D/E residues can cause translation discontinuation in eukaryotes, leading to biased amino acid usage in proteomes.

Nascent polypeptide within the exit tunnel ensures continuous translation elongation by stabilizing the translating ribosome

The paper identifies nascent polypeptides as stabilizers of the translating ribosome, preventing elongation abortion by counteracting intrinsic ribosome destabilization sequences.

Escherichia coli small heat shock protein IbpA is an aggregation-sensor that self-regulates its own expression at a translational level

The paper shows IbpA, an Escherichia coli small heat shock protein, self-regulates its expression by sensing protein aggregation and relieving translational repression when aggregated.