Author

T. Niwa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 3 Assay:proteomics· 3 Organism:E. coli· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

H. Taguchi· 3 shared Y. Chadani· 3 shared A. Yamakawa· 2 shared Y. Ito· 2 shared A. Kobo· 1 shared B. Temizoz· 1 shared C. T. Nguyen· 1 shared F. Takeshita· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersBiochemistry

H. Taguchi

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Latent inter-organ mechanism of idiopathic pulmonary fibrosis unveiled by a generative computational approach

S. Kozawa, K. Tejima, S. Takagi, M. Kuroda, M. Nogami-Itoh, H. Kitamura, T. Niwa, T. Ogura, Y. Natsume-Kitatani, T. N. Sato

This study identifies an inter-organ mechanism of idiopathic pulmonary fibrosis (IPF) using a generative computational approach, revealing a liver-lung crosstalk involving kininogen 1 and bradykinin receptor B1.

bioRxiv · Apr 18, 2023Pathology

A method to enrich polypeptidyl-tRNAs to capture snapshots of translation in the cell

A. Yamakawa, T. Niwa, Y. Chadani, A. Kobo, H. Taguchi

This paper introduces PETEOS, a method to enrich polypeptidyl-tRNAs for analysis of nascent proteins, and demonstrates its application in identifying proteins and observing translational responses to stress.

bioRxiv · Apr 22, 2022Biochemistry

Nascent peptide-induced translation discontinuation in eukaryotes impacts biased amino acid usage in proteomes

Y. Ito, Y. Chadani, T. Niwa, A. Yamakawa, K. Machida, H. Imataka, H. Taguchi

The paper shows that nascent peptides with consecutive D/E residues can cause translation discontinuation in eukaryotes, leading to biased amino acid usage in proteomes.

bioRxiv · Jan 27, 2022Biochemistry

Optimization of an LNP-mRNA vaccine candidate targeting SARS-CoV-2 receptor-binding domain

K. Kobiyama, M. Imai, N. Jounai, M. Nakayama, K. Hioki, K. Iwatsuki-Horimoto, S. Yamayoshi, J. Tsuchida, T. Niwa, T. Suzuki, M. Ito, S. Yamada, T. Watanabe, M. Kiso, H. Negishi, , K. J. Ishii

This study optimizes an LNP-mRNA vaccine targeting SARS-CoV-2 RBD by removing reactogenic materials, improving immunogenicity and protection in macaques.

bioRxiv · Mar 4, 2021 · PreprintImmunology

Nascent polypeptide within the exit tunnel ensures continuous translation elongation by stabilizing the translating ribosome

Y. Chadani, N. Sugata, T. Niwa, Y. Ito, S. Iwasaki, H. Taguchi

The paper identifies nascent polypeptides as stabilizers of the translating ribosome, preventing elongation abortion by counteracting intrinsic ribosome destabilization sequences.

bioRxiv · Feb 2, 2021Biochemistry