G. J. Kops

A farnesyl-dependent structural role for CENP-E in expansion of the fibrous corona

This study identifies a farnesyl-dependent structural role for CENP-E in fibrous corona expansion during mitosis, independent of its motor activity.

Predicting CIN rates from single-cell whole genome sequencing data using an in silico model

The paper develops an in silico model, CINsim, to predict chromosomal instability (CIN) rates from single-cell whole genome sequencing data by simulating karyotype dynamics and validating it in mouse and human cancer models.

Cyclin B1 scaffolds MAD1 at the corona to activate the spindle assembly checkpoint

This study identifies Cyclin B1 as a scaffold that localizes MAD1 to the kinetochore corona, enabling the spindle assembly checkpoint by making MAD1 phosphorylation independent of MPS1.

Interactions between N-terminal modules in MPS1 enable spindle checkpoint silencing

This study identifies an NTE-TPR interaction in MPS1 essential for SAC silencing by regulating MPS1 localization and delocalization from kinetochores.

Dynamic Kinetochore Size Regulation Promotes Microtubule Capture And Chromosome Biorientation In Mitosis

The paper shows that Spindly-based dynamic regulation of kinetochore size ensures proper microtubule capture and chromosome segregation by controlling corona expansion and shedding.