Angiotensin II receptor inhibition ameliorates liver fibrosis and enhances hepatocellular carcinoma infiltration by effector T cells
L. Gu, Y. Zhu, M. Lee, A. Nguyen, N. T. Ryujin, J. Huang, S. Chamseddine, L. Xiao, Y. I. Mohamed, A. O. Kaseb, M. Karin, S. Shalapour
This study shows that losartan, an angiotensin II receptor inhibitor, reduces liver fibrosis and enhances T cell infiltration in HCC, improving response to PD-1 blockade.
bioRxiv · Mar 5, 2023 · PreprintCancer Biology