Pharmacology & ToxicologybioRxivPreprint
A novel RyR1 inhibitor prevents and rescues sudden death in a mouse model of malignant hyperthermia and heat stroke
T. Yamazawa, T. Kobayashi, N. Kurebayashi…·T. Murayama
This study introduces a novel RyR1 inhibitor that prevents and rescues MH and heat stroke in mouse models, offering improved solubility and clearance compared to dantrolene.
DOI 10.1101/2020.07.02.185520