Y. Izumiya

KSHV Terminal Repeat Regulates Inducible Lytic Gene Promoters

This paper identifies KSHV terminal repeat (TR) as a regulatory domain that enhances lytic gene promoters through interactions with LANA and histone modifications.

Kaposis Sarcoma-Associated Herpesvirus (KSHV) LANA Prevents KSHV Episomes from Degradation

This study shows that KSHV LANA prevents viral genomic DNA degradation by inhibiting the cGAS-STING pathway, maintaining latency.

KSHV vIL-6 Enhances Inflammatory Responses by Epigenetic Reprogramming

This study shows that prolonged KSHV-encoded vIL-6 exposure reprograms chromatin to enhance inflammatory cytokine production through BRD4-mediated mechanisms.

KSHV uses viral IL6 to expand infected immunosuppressive macrophages

This study shows KSHV uses viral IL6 to expand infected immunosuppressive macrophages, aiding viral persistence and immune evasion.

Auxin-inducible Degron (AID) to Dissect Kaposi's Sarcoma associated Herpesvirus (KSHV) LANA protein function

This study uses an inducible degradation system to investigate KSHV LANA's role in latency and lytic reactivation, finding that LANA depletion reduces viral genome stability and lytic gene expression.

KSHV Topologically Associating Domains in Latent and Reactivated Viral Chromatin

This paper reveals the 3D chromatin structure of KSHV during latency and reactivation, showing similar TAD organization and reorganization of regulatory units.

Proximity Biotin Labeling Reveals KSHV Interferon Regulatory Factor Networks

This paper uses proximity labeling to identify KSHV vIRF-1 and vIRF-4 interacting proteins, revealing their roles in viral reactivation and innate immune regulation.