Author

T. Inagaki

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 8 Ecology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 7 Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Research Focus:chromatin & epigenetic regulation· 4 Approach:statistical model· 4 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2

Frequent Co-Authors

Y. Izumiya· 5 shared A. Kumar· 3 shared C. Tepper· 3 shared R. R. Davis· 3 shared C. Izumiya· 2 shared H. Kimura· 2 shared H. Miura· 2 shared J. M. Espera· 2 shared

Activity by Year

2020-2023 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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5 shared papersMicrobiology

Y. Izumiya

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Transmission dynamics of symbiotic protist communities in the termite gut: association with host adult eclosion and dispersal

T. Inagaki, K. Igai, K. Takahashi, Y. Hongoh

This study examines protist community dynamics during termite adult eclosion and dispersal, finding that changes in community composition enhance transmission efficiency.

bioRxiv · Sep 20, 2023Ecology

KSHV Terminal Repeat Regulates Inducible Lytic Gene Promoters

Y. Izumiya, A. Algalil, J. M. Espera, H. Miura, T. Inagaki, C. Izumiya, A. Kumar

This paper identifies KSHV terminal repeat (TR) as a regulatory domain that enhances lytic gene promoters through interactions with LANA and histone modifications.

bioRxiv · Sep 7, 2023 · PreprintMicrobiology

Kaposis Sarcoma-Associated Herpesvirus (KSHV) LANA Prevents KSHV Episomes from Degradation

K.-i. Nakajima, T. Inagaki, J. M. Espera, Y. Izumiya

This study shows that KSHV LANA prevents viral genomic DNA degradation by inhibiting the cGAS-STING pathway, maintaining latency.

bioRxiv · Aug 18, 2023Microbiology

Emergence of putative energy parasites within Clostridia revealed by genome analysis of a novel endosymbiotic clade

K. Takahashi, H. Kuwahara, Y. Horikawa, K. Izawa, D. Kato, T. Inagaki, M. Yuki, M. Ohkuma, Y. Hongoh

The paper identifies three endosymbiotic Clostridia in termite gut protists, revealing they are energy parasites with genome features suggesting obligate intracellular parasitism.

bioRxiv · Jul 3, 2023 · PreprintMicrobiology

KSHV vIL-6 Enhances Inflammatory Responses by Epigenetic Reprogramming

T. Inagaki, K.-H. Wang, A. Kumar, C. Izumiya, H. Miura, S. Komaki, R. R. Davis, C. Tepper, H. Katano, M. Shimoda, Y. Izumiya

This study shows that prolonged KSHV-encoded vIL-6 exposure reprograms chromatin to enhance inflammatory cytokine production through BRD4-mediated mechanisms.

bioRxiv · Jun 25, 2023Microbiology

KSHV uses viral IL6 to expand infected immunosuppressive macrophages

M. Shimoda, T. Inagaki, R. R. Davis, A. Merleev, C. Tepper, E. M. Maverakis, Y. Izumiya

This study shows KSHV uses viral IL6 to expand infected immunosuppressive macrophages, aiding viral persistence and immune evasion.

bioRxiv · Mar 5, 2023 · PreprintImmunology

KSHV Topologically Associating Domains in Latent and Reactivated Viral Chromatin

M. Campbell, C. Chantarasrivong, Y. Yanagihashi, T. Inagaki, R. R. Davis, K. Nakano, A. Kumar, C. Tepper, Y. Izumiya

This paper reveals the 3D chromatin structure of KSHV during latency and reactivation, showing similar TAD organization and reorganization of regulatory units.

bioRxiv · Apr 5, 2022Microbiology

A highly attenuated vaccinia virus strain LC16m8-based vaccine for severe fever with thrombocytopenia syndrome

T. Yoshikawa, S. Taniguchi, H. Kato, N. Iwata-Yoshikawa, H. Tani, T. Kurosu, H. Fujii, N. Omura, M. Shibamura, S. Watanabe, K. Egawa, T. Inagaki, S. Sugimoto, S. Phanthanawiboon, S. Harada, , M. Saijo

This paper develops and tests recombinant vaccinia virus vaccines against SFTS, showing they induce protective immunity and are safe in mice.

bioRxiv · Aug 6, 2020Microbiology

Epstein-Barr virus tegument protein BGLF2 in exosomes released from virus-producer cells assists de novo infection

Y. Sato, M. Yaguchi, Y. Okuno, H. Ishimaru, S. Ozaki, T. Suzuki, T. Inagaki, M. Umeda, T. Watanabe, M. Fujimuro, T. Murata, H. Kimura

This study identifies BGLF2, an EBV tegument protein, as being encapsulated in exosomes that enhance viral infection by boosting gene expression and suppressing innate immunity.

bioRxiv · Jun 22, 2020 · PreprintMicrobiology

Direct evidence of abortive lytic infection-mediated establishment of Epstein-Barr virus latency during B-cell infection

T. Inagaki, Y. Sato, J. Ito, M. Takaki, Y. Okuno, M. Yaguchi, H. M. A. A. Masud, T. Watanabe, K. Sato, S. Iwami, T. Murata, H. Kimura

The paper tracks EBV infection in B-cells using fate mapping and RNA-seq, showing abortive lytic infection precedes latency.

bioRxiv · Mar 23, 2020Microbiology