Hidden pathway for cytokine receptor activation: Structural insights into a marine sponge-derived lectin that activates the thrombopoietin receptor via recognition of the fucose moiety
H. Watari, H. Kageyama, N. Masubuchi, H. Nakajima, K. Onodera, P. J. Focia, T. Oshiro, T. Matsui, Y. Kodera, T. Ogawa, T. Yokoyama, M. Hirayama, K. Hori, D. M. Freymann, N. Komatsu, , R. Sakai
A marine sponge-derived lectin activates the thrombopoietin receptor by promoting dimerization and exhibits synergy with thrombopoietin, affecting receptor internalization.
bioRxiv · Oct 29, 2021 · PreprintCell Biology