N. Komatsu

Oxytocin receptor absence reduces selectivity in peer relationships and alters neurochemical release dynamics in prairie voles

This study shows that oxytocin receptor absence in prairie voles impairs peer relationship formation, stability, and reward, with reduced oxytocin release in the nucleus accumbens.

Artificial Intelligence Enables the Label-Free Identification of Chronic Myeloid Leukemia Cells with Mitochondrial Morphological Alterations

This study uses AI with flow cytometry to identify CML cells with mitochondrial morphological changes, enabling early diagnosis and monitoring of treatment response.

Transcriptional regulation of sphingolipid metabolism in budding yeast

This study identifies Com2 as a master transcriptional regulator of sphingolipid metabolism in yeast, showing it upregulates Ypk1 expression to control sphingolipid biosynthesis and response to environmental stress.

Hidden pathway for cytokine receptor activation: Structural insights into a marine sponge-derived lectin that activates the thrombopoietin receptor via recognition of the fucose moiety

A marine sponge-derived lectin activates the thrombopoietin receptor by promoting dimerization and exhibits synergy with thrombopoietin, affecting receptor internalization.

Harnessing the Cross-talk between Tumor Cells and Tumor-associated Macrophages with a Nano-drug for modulation of Glioblastoma Immune Microenvironment

This study demonstrates that Nano-DOX-loaded TAM can reprogram GBM cells to an anti-GBM phenotype through DAMP emission, enhancing immune response and reducing tumor growth.