T. Yokoyama

Single-fly assemblies fill major phylogenomic gaps across the Drosophilidae Tree of Life

The paper presents 183 new genome assemblies for 179 drosophilid species using single-fly long-read sequencing, improving phylogenomic coverage and enabling a well-resolved multi-locus phylogeny.

Unraveling the Genomic Diversity and Admixture History of Captive Tigers in the United States

This study analyzes the genomic diversity and admixture history of captive tigers in the U.S., finding admixture from all six wild tiger subspecies and developing a reference panel for conservation.

Genome-resolved meta-omics unveils rock-hosted lifestyle of enigmatic DPANN archaea

This study investigates the lifestyle of DPANN archaea in rock-hosted environments using genome-resolved meta-omics, revealing a symbiotic lifestyle and ecological interactions with bacteria and minerals.

Dose-response relationship for the resistance of human insulin to degradation by insulin-degrading enzyme

The paper investigates how human insulin resistance to degradation by IDE varies with dose and identifies structural features of the insulin hexamer that influence degradation kinetics without zinc.

Ciliary protein CEP290 regulates focal adhesion via microtubule system in non-ciliated cells

This study identifies a cilia-independent role of CEP290 in non-ciliated cells by regulating microtubule elongation and focal adhesion through its interaction with APC.

Structural basis of the transcription termination factor Rho engagement with transcribing RNA polymerase

The paper reports the cryo-EM structure of RNA polymerase engaged with Rho, revealing how Rho interacts with RNAP to mediate transcription termination.

Robust capability of renal tubule fatty acid uptake from apical and basolateral membranes in physiology and disease

This study investigates fatty acid uptake by renal tubule epithelial cells in mice, showing uptake from both blood and urine, and storage as neutral lipids, with CD36 playing a key role in blood-derived uptake.

Mechanistic insights into intramembrane proteolysis by E. coli site-2 protease homolog RseP

This study elucidates the mechanism of intramembrane proteolysis by E. coli RseP through crystal structures and mutational analysis, revealing a gating mechanism for substrate entry.

Hidden pathway for cytokine receptor activation: Structural insights into a marine sponge-derived lectin that activates the thrombopoietin receptor via recognition of the fucose moiety

A marine sponge-derived lectin activates the thrombopoietin receptor by promoting dimerization and exhibits synergy with thrombopoietin, affecting receptor internalization.

Characterization of γ-Glutamyl Peptidases and γ-Glutamyl Cyclotransferases for Glutathione Degradation in Arabidopsis

This study identifies GGP1 and GGP3 as key enzymes for glutathione degradation in Arabidopsis, showing they contribute significantly to cytosolic GSH turnover alongside GGCTs.

Direct observation of adaptive tracking on ecological timescales in Drosophila

The paper tracks phenotypic and genomic adaptation in Drosophila over ten generations, showing rapid and dynamic responses to environmental change.

Diagnosis of central serous chorioretinopathy by deep learning analysis of en face images of choroidal vasculature

This study uses deep learning to classify central serous chorioretinopathy from OCT images, achieving high accuracy with different models and showing DL focuses on choroidal vessel regions.

Genome-wide Association Studies Reveal Important Candidate Genes for the Bacillus pumilus TUAT-1-Arabidopsis thaliana Interaction

This study uses GWAS to identify candidate genes in Arabidopsis thaliana associated with root architecture changes in response to Bacillus pumilus TUAT-1 inoculation.

Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc

This paper reports the cryo-EM structure of the human LAT1-CD98hc heterodimer, revealing its architecture and interactions, and maps disease mutations to explain congenital disorders.

Changes in free amino acid concentrations and associated gene expression profiles in the abdominal muscle of kuruma shrimp Marsupenaeus japonicus reared at different salinity

This study examines how kuruma shrimp adjust free amino acid concentrations and gene expression in response to different salinity levels.

Neutrophil elastase inhibitor sivelestat ameliorates gefitinib-naphthalene-induced acute pneumonitis in mice

This study shows that sivelestat reduces gefitinib-induced pneumonitis in mice by lowering neutrophil elastase activity and improving survival.