Specific decreasing of Na+ channel expression on the lateral membrane of cardiomyocytes causes fatal arrhythmias in Brugada syndrome
K. Tsumoto, T. Ashihara, N. Naito, T. Shimamoto, A. Amano, Y. Kurata, Y. Kurachi
This study shows that reduced Na+ channel expression in the lateral membrane of cardiomyocytes leads to phase-2 reentry, causing lethal arrhythmias in Brugada syndrome.
bioRxiv · Oct 16, 2019Biophysics