K. Hayashi

Sexual dimorphism in the tardigrade Paramacrobiotus metropolitanus transcriptome

This study identifies sex-biased genes and DMRT paralogs in the tardigrade Paramacrobiotus metropolitanus, revealing insights into sexual dimorphism and stress tolerance mechanisms.

High-fat diets promote peritoneal inflammation and augment endometriosis-associated abdominal hyperalgesia

This study shows high-fat diets worsen endometriosis-related abdominal pain by increasing peritoneal inflammation and pain mediators.

Engineered Active Zymogen of Microbial Transglutaminase

This paper designs an engineered active zymogen of microbial transglutaminase (EzMTG) that exhibits cross-linking activity without requiring proteolysis, and identifies mutations that balance binding affinity and catalytic activity.

Spatio-temporal Coordination of Active Deformation Forces and Wnt / Hippo-Yap Signaling in Hydra Regeneration

The paper investigates how Wnt signaling and tissue deformation coordinate during Hydra regeneration, finding that biomechanical symmetry breaking is regulated by Wnt and stabilized by Hippo-Yap signaling.

Number of kinesins engaged in axonal cargo transport: A novel biomarker for neurological disorders

The paper reviews a model to quantify kinesin molecules engaged in axonal cargo transport and suggests their number could serve as biomarkers for neurodegenerative diseases.

The highly developed symbiotic system between the solar-powered nudibranch Pteraeolidia semperi and Symbiodiniacean algae

This study examines the symbiotic relationship between the nudibranch Pteraeolidia semperi and Symbiodiniacean algae, revealing its complex structure and bleaching processes.

The impact of sex and physical activity on the local immune response to muscle pain

This study examines how sex and physical activity influence the immune response to muscle pain in mice, finding sex-specific effects on immune pathways and macrophage phenotypes.

Megacolonies: an alternative social organization in anemonefishes?

The paper describes the discovery of 'megacolonies' in anemonefishes, which exhibit a different social structure compared to typical colonies, with reduced size-based hierarchy and aggression.

An attenuated vaccinia vaccine encoding the SARS-CoV-2 spike protein elicits broad and durable immune responses, and protects cynomolgus macaques and human ACE2 transgenic mice from SARS-CoV-2 and its variants

This study develops a vaccinia-based vaccine encoding SARS-CoV-2 spike protein that induces broad and durable immunity, protecting against multiple variants in non-human primates and transgenic mice.

Extreme value analysis of intracellular cargo transport by motor proteins

The paper applies extreme-value analysis to study motor protein transport in C. elegans neurons, finding differences in distribution shape parameters between anterograde and retrograde transport.

Intracellular force comparison of pathogenic KIF1A, KIF5, and dynein by fluctuation analysis

The paper compares intracellular force and velocity of KIF1A, KIF5, and dynein using fluctuation analysis and finds impaired force and velocity in specific KIF1A variants.

Vapor cannabis exposure generationally affects male reproductive functions in mice

This study shows that cannabis vapor exposure in adult male mice reduces sperm count and motility in F0 and F1 generations but not F2, and disrupts spermatogenesis and DNA methylation in F1 testes.

De novo disease-associated mutations in KIF1A dominant negatively inhibit axonal transport of synaptic vesicle precursors

This study establishes C. elegans models for KIF1A-associated neuronal disorder and shows that disease mutations inhibit wild-type KIF1A function in heterodimers.

Effects of the dynein inhibitor dynarrestin on the number of motor proteins transporting synaptic cargos

The paper measures how dynarrestin affects motor protein transport by estimating force-producing units in hippocampal neurons.

Neutralizing antibody-dependent and -independent immune responses against SARS-CoV-2 in cynomolgus macaques

This study examines immune responses in cynomolgus macaques infected with SARS-CoV-2, showing both neutralizing antibodies and IFN-γ-producing T-cells contribute to viral clearance.

The ER cholesterol sensor SCAP promotes CARTS biogenesis at ER-Golgi contact sites

The paper shows SCAP facilitates CARTS biogenesis at ER-Golgi contact sites by regulating cholesterol and PI4P exchange under cholesterol-fed conditions.

Proteolytic Cleavage by Matriptase Exacerbating Kidney Injury: a Novel Therapeutic Target

This study identifies Matriptase cleavage of Podocin as a mechanism of podocyte injury in CKD, suggesting Matriptase inhibition as a therapeutic strategy.

Multiple Dynamical Mechanisms of Phase-2 Early Afterdepolarizations in a Human Ventricular Myocyte Model: Involvement of spontaneous SR Ca2+ release

This study investigates the dynamical mechanisms of phase-2 early afterdepolarizations (EADs) in human ventricular myocytes using a modified ten Tusscher-Panfilov model, revealing two distinct EAD initiation mechanisms and their relationship to bifurcation phenomena.

Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response

This study identifies a PRMT7 inhibitor and shows its effect on arginine methylation of stress proteins, linking PRMT7 to cellular stress response.

Application of the fluctuation theorem for non-invasive force measurement in living neuronal axons

The paper applies the fluctuation theorem to measure non-invasive forces on endosomes in axonal transport, finding that single cargo vesicles are conveyed by one to three or four units of force.