Induction of selective cell death in HIV-1-infected cells by DDX3 inhibitors leads to depletion of the inducible reservoir
S. Rao, C. Lungu, R. Crespo, T. H. Steijaert, A. Gorska, R.-J. Palstra, H. A. B. Prins, W. van Ijcken, C. Rokx, Y. M. Mueller, J. J. A. Van Kampen, A. Verbon, P. D. Katsikis, C. A. B. Boucher, R. A. Gruters, T. Mahmoudi
This study shows DDX3 inhibitors induce selective apoptosis in HIV-1-infected cells, reducing the inducible latent HIV-1 reservoir.
bioRxiv · Aug 26, 2020Microbiology