Author

T. Mahmoudi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Bioengineering· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Assay:scRNA-seq· 2 Research Focus:clustering· 1

Frequent Co-Authors

S. Rao· 4 shared R.-J. Palstra· 3 shared T. W. Kan· 3 shared A. Gorska· 2 shared C. Lungu· 2 shared M. M. Khalid· 2 shared R. Crespo· 2 shared A. Ahmadian· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersMicrobiology

S. Rao

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

PCID2 dysregulates transcription and viral RNA processing to promote HIV-1 latency

R. Crespo, E. Ne, J. Reinders, J. I. J. Meier, C. Li, S. Jansen, A. Gorska, S. Kocer, T. W. Kan, W. Doff, D. Dekkers, J. Demmers, R. J. Palstra, S. Rao, T. Mahmoudi

This study identifies PCID2 as a novel HIV-1 latency-promoting factor that represses transcription and dysregulates viral RNA processing through its role in the TREX2 complex.

bioRxiv · Sep 21, 2023Microbiology

SQuHIVLa: A novel assay for Specific Quantification of inducible HIV-1 reservoir by LAMP

T. Hossain, C. Lungu, S. de Schrijver, M. Kuali, S. Rao, A. Ngubane, T. W. Kan, R.-J. Palstra, P. Madlala, T. Ndung'u, T. Mahmoudi

SQuHIVLa quantifies inducible HIV-1 reservoirs in CD4+ T cells using a sensitive and specific RT-LAMP assay, showing high throughput and scalability.

bioRxiv · Jul 14, 2023 · PreprintMicrobiology

Hepatitis C Virus Infects and Perturbs Liver Stem Cells

N. L. Meyers, T. Ashuach, D. E. Lyons, C. R. Simoneau, A. L. Erickson, T. T. Nguyen, M. Bouhaddou, M. M. Khalid, T. Y. Taha, V. Natarajan, J. L. Baron, N. Neff, F. Zanini, T. Mahmoudi, S. R. Quake, , M. Ott

This study identifies liver stem cells as targets of HCV infection, showing their transcriptional reprogramming and role in liver damage and cancer risk.

bioRxiv · Oct 26, 2021Microbiology

Segmentation of Pancreatic Ductal Adenocarcinoma (PDAC) and surrounding vessels in CT images using deep convolutional neural networks and Texture Descriptors

T. Mahmoudi, Z. Mousavi Kouzehkanan, A. Radmard, R. Kafieh, A. Salehnia, A. H. Davarpanah, H. Arabalibeik, A. Ahmadian

This paper proposes a deep learning framework for automated segmentation of PDAC and surrounding vessels in CT images, achieving improved Dice scores using 3D-CNN and texture descriptors.

bioRxiv · Jun 9, 2021Bioengineering

Human liver organoids; a patient-derived primary model for HBV Infection and Related Hepatocellular Carcinoma

E. De Crignis, S. Romal, F. Carofiglio, P. Moulos, M. M. A. Verstegen, M. M. Khalid, F. Pourfarzad, S. Rao, A. Bazrafshan, C. Koutsothanassis, H. Gehart, T. W. Kan, R.-J. Palstra, C. Boucher, J. IJzermans, , T. Mahmoudi

This paper establishes human liver organoids as a model for HBV infection and HCC, showing they support viral replication, produce infectious HBV, and exhibit cancer-related gene signatures.

bioRxiv · Nov 11, 2020Cancer Biology

Induction of selective cell death in HIV-1-infected cells by DDX3 inhibitors leads to depletion of the inducible reservoir

S. Rao, C. Lungu, R. Crespo, T. H. Steijaert, A. Gorska, R.-J. Palstra, H. A. B. Prins, W. van Ijcken, C. Rokx, Y. M. Mueller, J. J. A. Van Kampen, A. Verbon, P. D. Katsikis, C. A. B. Boucher, R. A. Gruters, T. Mahmoudi

This study shows DDX3 inhibitors induce selective apoptosis in HIV-1-infected cells, reducing the inducible latent HIV-1 reservoir.

bioRxiv · Aug 26, 2020Microbiology