Pharmacology & ToxicologyThe Journal of Pharmacology and Experimental TherapeuticsPeer-reviewed
Potent, Gut-Restricted Inhibitors of Divalent Metal Transporter 1 (DMT1): Preclinical Efficacy Against Iron Overload and Safety Evaluation
A. J. Cutts, S. Chowdhury, L. Ratkay…·C. J. Cohen
This paper identifies XEN602, a potent, gut-restricted DMT1 inhibitor, showing efficacy in reducing iron overload in rats and pigs with minimal systemic exposure.
DOI 10.1124/jpet.122.001435