Author

C. J. Cohen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Pharmacology & Toxicology· 3

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Assay:electrophysiology· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 1 Organism:plant (other)· 1 Organism:rat· 1

Frequent Co-Authors

M. Waldbrook· 3 shared A. J. Cutts· 2 shared F. Scott· 2 shared J. Johnson· 2 shared J. Mezeyova· 2 shared J. R. Empfield· 2 shared L. Sojo· 2 shared M. Grimwood· 2 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersPharmacology & Toxicology

M. Waldbrook

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Molecular pharmacology of selective NaV1.6 and dual NaV1.6 and NaV1.2 channel inhibitors that suppress excitatory neuronal activity ex vivo

S. J. Goodchild, N. G. Shuart, A. D. Williams, W. Ye, R. R. Parrish, M. Soriano, S. Thouta, J. Mezeyova, M. Waldbrook, R. A. Dean, T. Focken, M.-R. Ghovanloo, P. C. Ruben, F. Scott, C. J. Cohen, , J. Johnson

This paper introduces selective NaV1.6 and dual NaV1.6/NaV1.2 inhibitors that suppress excitatory neuronal activity ex vivo, showing selectivity over NaV1.1 and efficacy in seizure models.

bioRxiv · Aug 3, 2023Pharmacology & Toxicology

NaV1.6 inhibition drives the efficacy of voltage-gated sodium channel inhibitors to prevent electrically induced seizures in both wild type and Scn8aN1768D/+ gain-of-function mice

J. Johnson, T. Focken, P. K. Tari, C. Dube, S. J. Goodchild, J.-C. Andrez, G. Bankar, K. Burford, E. Chang, S. Chowdhury, J. Christabel, R. A. Dean, G. de Boer, C. Dehnhardt, W. Gong, , J. R. Empfield

The paper shows that inhibiting NaV1.6 reduces seizures in both wild-type and Scn8aN1768D/+ mice, suggesting NaV1.6 is a key target for anti-seizure drugs.

bioRxiv · Aug 3, 2023 · PreprintPharmacology & Toxicology

Potent, Gut-Restricted Inhibitors of Divalent Metal Transporter 1 (DMT1): Preclinical Efficacy Against Iron Overload and Safety Evaluation

A. J. Cutts, S. Chowdhury, L. Ratkay, M. Eyers, C. Young, R. Namdari, J. Cadieux, N. Chahal, M. Grimwood, Z. Zhang, S. Lin, I. Tietjen, Z. Xie, L. Robinette, L. Sojo, , C. J. Cohen

This paper identifies XEN602, a potent, gut-restricted DMT1 inhibitor, showing efficacy in reducing iron overload in rats and pigs with minimal systemic exposure.

bioRxiv · Sep 1, 2022Pharmacology & Toxicology