A. Thakur

Evolutionary sequence and structural basis for the distinct conformational landscapes of Tyr and Ser/Thr kinases

The paper investigates the structural basis for the distinct conformational landscapes of tyrosine and serine/threonine kinases using sequence and structure-based models.

FORMATION OF MALIGNANT, METASTATIC SMALL CELL LUNG CANCERS THROUGH OVERPRODUCTION OF cMYC PROTEIN IN TP53 AND RB1 DEPLETED PULMONARY NEUROENDOCRINE CELLS DERIVED FROM HUMAN EMBRYONIC STEM CELLS

This study shows that overproducing cMYC in TP53 and RB1-depleted hESC-derived PNECs leads to aggressive SCLC-like tumors with metastatic properties and NEUROD1 expression.

HYENA detects oncogenes activated by distal enhancers in cancer

HYENA identifies oncogenes, including non-coding genes, activated by enhancer hijacking in cancer using whole-genome and transcriptome sequencing data.

The protozoan commensal Tritrichomonas musculis is a natural adjuvant for mucosal IgA.

This study shows that the protozoan commensal Tritrichomonas musculis promotes T-cell dependent IgA class-switch recombination and enhances IgA-secreting plasma cell accumulation and dissemination.

Evolutionary Divergence in the Conformational Landscapes of Tyrosine vs Serine/Threonine Kinases

The paper investigates conformational differences between tyrosine and serine/threonine kinases using sequence analysis and simulations to explain binding affinity differences for type-II inhibitors.

CYCLODEXTRIN DERIVATIVE ENHANCES THE OPHTHALMIC DELIVERY OF POORLY SOLUBLE AZITHROMYCIN.

This paper develops an in situ gel formulation of azithromycin with sulfobutylether-β-cyclodextrin to improve ocular delivery and antimicrobial efficacy for treating bacterial conjunctivitis.

GNNQQNY: Methodology for biophysical and structural understanding of aggregation

This study describes a solubilisation protocol for GNNQQNY peptides that enables the study of amyloid fibril formation kinetics and thermodynamics.

Protein reservoirs of seeds are composites of amyloid and amyloid-like structures facilitating sustained release during germination and seedling growth

This study identifies amyloid and amyloid-like structures in plant seed storage protein bodies (SSPB) and demonstrates their role in controlling germination and seedling growth.

Regeneration of lung epithelial cells by Fullerene C60 nanoformulation: A possible treatment strategy for acute respiratory distress syndrome (ARDS)

This paper demonstrates that a Fullerene C60 nanoformulation can regenerate lung epithelial cells exposed to apoptosis-inducing molecules, suggesting its potential as a treatment for ARDS.

Multiple dimensions of social motivation in adult female degus

This study investigates social motivation in female degus by analyzing reunion behaviors after isolation or separation, identifying both general and peer-specific drives through behavioral and vocal interaction patterns.

Accelerated tissue repair through cell proliferative effect by a size controlled aqueous based Fullerene C60 nanoformulation

The paper develops a size-controlled aqueous Fullerene C60 nanoformulation that promotes cell proliferation and tissue repair in cellular and animal models.

Novel PE and APC Tandems: Additional Near-Infrared Fluorochromes for Use in Spectral Flow Cytometry

The paper introduces six new near-infrared fluorochromes for spectral flow cytometry, enhancing the number of available fluorochromes for 3-laser systems.

Rub1/NEDD8, a ubiquitin-like modifier, is also a ubiquitin modifier

This paper shows that a single amino acid swap at position 72 can switch the substrate specificity of Rub1/NEDD8 and ubiquitin, revealing their distinct roles in cellular modification pathways.

Investigation of a night soil compost psychrotrophic bacterium Glutamicibacter arilaitensis LJH19 for its safety, efficient hydrolytic and plant growth-promoting potential

A Drosophila model of oral peptide therapeutics for adult intestinal stem cell tumors

This paper evaluates the efficacy of a TONDU peptide in suppressing Yki-driven intestinal stem cell tumors in Drosophila by inhibiting YAP-TEAD interaction and modulating integrin signaling.

Predicting glaucoma prior to its onset using deep learning

This study uses deep learning to predict glaucoma development from fundus photographs years before onset, achieving an AUC of 0.77 for 4-7 years prior and 0.88 for 1-3 years prior.