Activation of the IKK2-NFκB pathway in VSMCs inhibits calcified vascular stiffness in CKD by reducing the secretion of calcifying extracellular vesicles.
S. Miyazaki, M. Masuda, A. L. Keenan, Y. Shiozaki, M. Miyazaki
This study shows that activating the IKK2-NFκB pathway in vascular smooth muscle cells reduces calcifying extracellular vesicles, thereby decreasing vascular stiffness in CKD.
bioRxiv · Jul 11, 2023 · PreprintPhysiology