M. Miyazaki

Protein design of two-component tubular assemblies like cytoskeletons

This paper introduces NIPAD, a method to design two-component tubular protein assemblies that mimic biological structures like actin and microtubules, showing dynamic flexibility and reversible assembly.

Activation of the IKK2-NFκB pathway in VSMCs inhibits calcified vascular stiffness in CKD by reducing the secretion of calcifying extracellular vesicles.

This study shows that activating the IKK2-NFκB pathway in vascular smooth muscle cells reduces calcifying extracellular vesicles, thereby decreasing vascular stiffness in CKD.

Liver type 1 innate lymphoid cells lacking IL-7 receptor are a native killer cell subset fostered by parenchymal niches

The paper identifies a novel liver-specific ILC1 subset lacking IL-7 receptor that develops from fetal liver progenitors and exhibits constitutive cytotoxic activity.

T cell-intrinsic vitamin A metabolism and its signaling are targets for memory T cell-based cancer immunotherapy

This study identifies vitamin A metabolism and its signaling as regulators of memory T cell differentiation and shows their potential as targets for cancer immunotherapy.

Tracking Action in Cross-Reality Mark Test Reveals Developing Body Representation Among Toddlers

This study introduces Bodytoypo, a cross-reality task to assess body representation in toddlers, finding age-related changes in how visual and motor information are integrated during body-part localization.

A Novel Mouse Wound Model for Scar Tissue Formation in Abdominal-Muscle Wall

The paper develops a novel mouse model for scar tissue formation in the abdominal muscle wall without artificial factors, showing collagen-rich granulation tissue similar to human scars.

Isolation of an archaeon at the prokaryote-eukaryote interface

The paper isolates an Asgard archaeon and proposes a symbiosis model for eukaryogenesis based on its morphology and metabolism.