M. Masuda

Label-free imaging of intracellular structures in living mammalian cells via external apodization phase-contrast microscopy

This study introduces ExAPC microscopy for label-free visualization of intracellular structures, showing its ability to resolve biomolecular condensates, lipid droplets, and mitochondria with high spatiotemporal resolution.

Activation of the IKK2-NFκB pathway in VSMCs inhibits calcified vascular stiffness in CKD by reducing the secretion of calcifying extracellular vesicles.

This study shows that activating the IKK2-NFκB pathway in vascular smooth muscle cells reduces calcifying extracellular vesicles, thereby decreasing vascular stiffness in CKD.

T cell-specific P2RX7 favors lung parenchymal CD4+ T cell accumulation in response to severe lung infections

This study shows that T cell-specific P2RX7 promotes lung CD4+ T cell accumulation and pathology during severe lung infections like TB and influenza.

All-trans retinoic acid induces GADD34 gene expression via transcriptional regulation by Six1-TLE3 and post-transcriptional regulation by p38-TTP in skeletal muscle

This study shows ATRA increases GADD34 expression in muscle through transcriptional activation and post-transcriptional stabilization, altering myosin heavy chain types in myotubes.

Atypical integrative element with strand-biased circularization activity assists interspecies antimicrobial resistance gene transfer from Vibrio alfacsensis

This study identifies a new type of mobile genetic element, SEs, that facilitates AMR gene transfer between marine bacteria by strand-biased circularization.