Cryo-EM structure of the human Mixed Lineage Leukemia-1 complex bound to the nucleosome
S. h. Park, A. Ayoub, Y. T. Lee, J. Xu, H. Kim, W. Zhang, B. Zhang, S. An, Y. Zhang, M. A. Cianfrocco, M. Su, Y. Dou, u.-s. cho
The paper reports the cryo-EM structure of the human MLL1 complex bound to the nucleosome, revealing how it interacts with histone H3K4 and promotes tri-methylation.
bioRxiv · Aug 16, 2019Biochemistry