Author

A. Ayoub

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Immunology· 2 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 3 Assay:cryo-EM· 2 Research Focus:differential expression· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:protein structure prediction· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

K. Ask· 3 shared M. Vierhout· 2 shared S. H. Park· 2 shared S. Naiel· 2 shared U.-S. Cho· 2 shared Y. Dou· 2 shared A. C. Doxey· 1 shared A. Dvorkin-Gheva· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersImmunology

K. Ask

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Author profile →

5 papers

Recent·Most cited

A Novel Ex Vivo Approach for Investigating Profibrotic Macrophage Polarization Using Murine Precision-Cut Lung Slices

M. Vierhout, A. Ayoub, P. Ali, V. Kumaran, S. Naiel, T. Isshiki, J. F. Koenig, M. R. Kolb, K. Ask

This paper develops an ex vivo model using murine precision-cut lung slices to study profibrotic macrophage polarization and validates its utility for fibrosis research.

bioRxiv · Jul 5, 2024Immunology

MLL1 Methyltransferase Activity is Regulated by Distinct Nucleosome Binding Modes

A. Ayoub, S. H. Park, Y.-t. Lee, U.-S. Cho, Y. Dou

The paper determines the cryoEM structure of the MLL1 complex bound to a nucleosome and identifies two binding modes, one of which is catalytically inactive.

bioRxiv · Apr 13, 2021Biochemistry

ABCF1 regulates dsDNA-induced immune responses in human airway epithelial cells

Q. T. Cao, J. A. Aguiar, B. J.-M. Tremblay, N. Abbas, N. Tiessen, S. Revill, N. Makhdami, A. Ayoub, G. Cox, K. Ask, A. C. Doxey, J. A. Hirota

This study identifies ABCF1 as a cytosolic nucleic acid sensor in human airway epithelial cells that modulates antiviral responses and interacts with TLR signaling.

bioRxiv · Feb 8, 2020Immunology

FK506-binding protein 13 expression is upregulated in interstitial lung disease and correlated with clinical severity: a potentially protective role.

V. Tat, E. A. Ayaub, A. Ayoub, M. Vierhout, S. Naiel, M. Padwal, S. Abed, O. Mekhael, K. Tandon, S. D. Revill, T. Yousof, P.-S. Bellaye, P. Kolb, A. Dvorkin-Gheva, A. Naqvi, , K. Ask

This study shows FKBP13 is upregulated in interstitial lung diseases and correlates with disease severity, suggesting a protective role against fibrosis.

bioRxiv · Dec 15, 2019Pathology

Cryo-EM structure of the human Mixed Lineage Leukemia-1 complex bound to the nucleosome

S. h. Park, A. Ayoub, Y. T. Lee, J. Xu, H. Kim, W. Zhang, B. Zhang, S. An, Y. Zhang, M. A. Cianfrocco, M. Su, Y. Dou, u.-s. cho

The paper reports the cryo-EM structure of the human MLL1 complex bound to the nucleosome, revealing how it interacts with histone H3K4 and promotes tri-methylation.

bioRxiv · Aug 16, 2019Biochemistry