STAT1 Gain-of-Function Variants Drive Altered T Cell Prevalence, Metabolism, and Heightened IL-6 Sensitivity
S. Kaviany, T. Bartkowiak, D. E. Dulek, Y. W. Khan, M. J. Hayes, S. K. Schaefer, D. O. Dahunsi, J. A. Connelly, J. M. Irish, J. C. Rathmell
This study identifies how STAT1 gain-of-function variants alter T cell prevalence, metabolism, and IL-6 sensitivity in patients, revealing their role in immune dysregulation.
bioRxiv · Nov 10, 2021 · PreprintImmunology