J. C. Rathmell

Metabolite profiling of human renal cell carcinoma reveals tissue-origin dominance in nutrient availability

This study profiles metabolites in renal cell carcinoma tissue and fluid to show that nutrient availability is more influenced by tissue-specific factors than tumor-driven changes.

Plasma cell differentiation, antibody quality, and initial germinal center B cell population depend on glucose influx rate

This study shows that glucose influx is critical for germinal center function and plasma cell production, but plasma cells can also use alternative hexose sugars for antibody secretion.

Functional Overlap of Inborn Errors of Immunity and Metabolism Genes Define T Cell Immunometabolic Vulnerabilities

The paper identifies functional overlap between inborn errors of immunity and metabolism genes, revealing immunometabolic vulnerabilities in T cells.

PD-1 is induced on tumor-associated macrophages in obesity to directly restrain anti-tumor immunity

This study shows obesity induces PD-1 on tumor-associated macrophages, which suppresses anti-tumor immunity by altering metabolic and functional properties of these cells.

ACSS2 Regulates HIF-2α Degradation through the E3-Ubiquitin Ligase MUL1 in Clear Cell Renal Cell Carcinoma

This study shows ACSS2 promotes HIF-2 stability by preventing its interaction with MUL1, and inhibiting ACSS2 reduces HIF-2 levels and suppresses ccRCC growth.

STAT1 Gain-of-Function Variants Drive Altered T Cell Prevalence, Metabolism, and Heightened IL-6 Sensitivity

This study identifies how STAT1 gain-of-function variants alter T cell prevalence, metabolism, and IL-6 sensitivity in patients, revealing their role in immune dysregulation.

Single-Cell Profiling of the Antigen-Specific Response to BNT162b2 SARS-CoV-2 RNA Vaccine

Multiplatform Computational Analysis of Mast Cells in Adrenocortical Carcinoma Tumor Microenvironment

The paper uses computational analysis to identify mast cell signatures in ACC tumor microenvironment, finding anti-tumor associations with improved survival.

Multiplatform Integrative Analyses of Immunosuppressive Signatures in Cortisol-secreting Adrenocortical Carcinoma

This study identifies immunosuppressive signatures in cortisol-secreting adrenocortical carcinoma (CS-ACC) through multiplatform immunogenomic analyses, linking these signatures to poor prognosis and immunotherapy resistance.

Cell Programmed Nutrient Partitioning in the Tumor Microenvironment

The paper measures nutrient uptake in the tumor microenvironment using PET tracers and finds cancer cells prefer glutamine while myeloid cells consume most glucose.

Single-cell metabolic dynamics of early activated CD8 T cells during the primary immune response to infection

The paper examines metabolic dynamics in early activated CD8 T cells during the primary immune response, identifying a transient state with maximal glycolytic and oxidative metabolic activity.

Antigen receptor control of methionine metabolism in T cells

This study shows antigen receptor engagement controls methionine cycle flux and methyl donor availability for RNA and histone methylation in T cells.