Pharmacology & ToxicologybioRxiv
Facilitation of hERG channels by blockers: a mechanism predicted to reduce lethal cardiac arrhythmias
K. Furutani, K. Tsumoto, I.-S. Chen…·Y. Kurachi
This paper proposes that hERG channel facilitation by blockers can reduce lethal cardiac arrhythmias by preventing early afterdepolarizations during repolarization.
DOI 10.1085/jgp.201812192