Structural analysis of the PTEN:P-Rex2 signalling node reveals how cancer-associated mutations coordinate to hyperactivate Rac1
L. D'Andrea, C. M. Lucato, E. A. Marquez, Y.-G. Chang, S. Civciristov, C. Huang, H. Elmlund, R. B. Schittenhelm, C. A. Mitchell, J. C. Whisstock, M. L. Halls, A. M. Ellisdon
The paper investigates the PTEN:P-Rex2 complex, identifying how cancer mutations disrupt its inhibitory function and hyperactivate Rac1 signaling.
bioRxiv · Apr 11, 2020Biochemistry