SPARC promotes insulin secretion through down-regulation of RGS4 protein in pancreatic beta-cells
L. Hu, F. He, M. Huang, Q. Zhao, L. Cheng, N. Said, Z. Zhou, F. Liu, Y.-S. Dai
This study shows SPARC enhances insulin secretion by reducing RGS4 in pancreatic beta-cells, improving glucose tolerance in SPARC-deficient mice.
bioRxiv · Jan 11, 2020Cell Biology