Q. Zhao

Unraveling the Role of Ctla-4 in Intestinal Immune Homeostasis: Insights from a novel Zebrafish Model of Inflammatory Bowel Disease

This study identifies a zebrafish model of IBD by knocking out Ctla-4, showing similar intestinal inflammation and immune dysregulation to mammalian IBD.

YTHDF2 upregulation and relocation dictate CD8 T cell polyfunctionality in tumor immunity

This paper shows YTHDF2 upregulation and nuclear relocation enhance CD8 T cell polyfunctionality and tumor immunity by regulating gene transcription and mitochondrial fitness.

Engineering programmable CAR-T cells with tunable controls as fail-safe mechanisms during cancer immunotherapy

This study develops a synthetic biology toolbox to engineer CAR-T cells with tunable controls, enabling safe and effective cancer immunotherapy through fail-safe mechanisms.

An efficient method for visualizing the plaques of Bdellovibrio bacteriovorus

This paper introduces a method using fluorescent prey to visualize Bdellovibrio bacteriovorus plaques faster, reducing incubation time from 3 days to 1.5 days.

Unveiling the mechanisms of black phosphorus nanosheets-induced viable but non-culturable state in Bacillus tropicus

This study investigates how black phosphorus nanosheets induce a viable but non-culturable state in Bacillus tropicus, revealing suppressed metabolism and respiratory pathways as key mechanisms.

Multiomic Screening Unravels the Immunometabolic Signatures and Drug Targets of Age-Related Macular Degeneration

This study uses multiomic methods to identify immunometabolic pathways and drug targets in AMD, highlighting key genes and pathways involved in disease progression and potential therapeutic interventions.

Influences of single mutation and retinal binding on the THz absorption spectra of CRABP-II based rhodopsin mimics

This study uses THz-TDS to analyze how retinal binding and single mutations affect the low-frequency absorption spectra of rhodopsin mimics.

Nanocluster-antibody-drug conjugates (NADC) as an intravesical precision theranostic agent for interstitial cystitis

This paper develops a nanocluster-antibody-drug conjugate (NADC) for interstitial cystitis, showing it targets NGF-overexpressing bladder lesions and reduces inflammation in rat models.

The origin and evolution of cultivated rice and genomic signatures of heterosis for yield traits in super-hybrid rice

This study investigates the evolutionary history of cultivated rice and identifies genomic signatures of heterosis in super-hybrid rice varieties.

High-Resolution Spatial Transcriptomic Atlas of Mouse Soleus Muscle: Unveiling Single Cell and Subcellular Heterogeneity in Health and Denervation

CD81+ senescent-like fibroblasts exaggerate inflammation and activate neutrophils via C3/C3aR1 axis in periodontitis

This study identifies CD81+ senescent fibroblasts as key drivers of inflammation in periodontitis through the C3/C3aR1 axis and shows that senolytics and metformin can reduce inflammation and bone loss.

Jianpi Jiedu Recipe inhibits proliferation through reactive oxygen species-induced incomplete autophagy and reduces PD-L1 expression in colon cancer

Organelle proteomic profiling reveals lysosomal heterogeneity in association with longevity

This study uses proteomic profiling to reveal lysosomal heterogeneity and its role in longevity by identifying protein dynamics and interactions in lysosomes.

Unbiased Complete Estimation of Chloroplast Number in Plant Cells Using Deep Learning Methods

This paper introduces a deep learning method for accurate 3D chloroplast counting in plant cells, achieving over 95% accuracy compared to manual methods.

Umbrella toxin particles produced by Streptomyces block mycelial growth of competing species

This study identifies umbrella toxin particles produced by Streptomyces that inhibit the growth of competing bacterial species, distinct from small molecule antibiotics.

Unveiling unique microbial nitrogen cycling and novel nitrification drivers in coastal Antarctica

This study identifies unique microbial nitrogen cycling mechanisms in coastal Antarctica, highlighting the role of comammox Nitrospira in nitrification.

hURAT1 Transgenic Mouse Model for Evaluating Targeted Urate-Lowering Agents

This paper develops a human URAT1 transgenic mouse model to evaluate urate-lowering agents and study URAT1-related pathogenesis in gout.

NLRP3 Cys126 palmitoylation by ZDHHC7 Promotes Inflammasome Activation

This study identifies ZDHHC7-mediated palmitoylation of NLRP3 at Cys126 as critical for inflammasome activation, with implications for therapeutic targeting of inflammatory diseases.

Is M1-L121E a good mimic on microbial rhodopsin? A viewpoint from excited-state dynamics

This paper investigates the excited-state dynamics of a microbial rhodopsin mimic, M1-L121E, and finds it captures key features but shows distinct differences in photoreaction dynamics compared to natural rhodopsin.

Crohn's patients and healthy infants share immunodominant B cell response to commensal flagellin peptide epitopes

The paper identifies a shared B cell response to a conserved flagellin epitope in Crohn's disease patients and healthy infants, suggesting a potential early failure of homeostatic immunity.

An mTOR/RNA pol I axis shapes chromatin architecture in response to fasting

This study shows fasting induces large-scale chromatin reorganization in C. elegans, requiring mTOR inhibition and RNA Pol I activity.

Nanobead-based single-molecule pulldown for single cells

This paper introduces a nanobead-based single-cell single-molecule pulldown (sc-SiMPull) method that is faster, easier, and more versatile than existing techniques for studying protein-protein interactions in single cells.

GDF15 is a Critical Renostat in the Defense Against Hypoglycemia

This study identifies GDF15 as a new hypoglycemia counterregulatory hormone, showing it increases hepatic gluconeogenesis through renal release and beta-adrenergic receptor-2 signaling.

Endosome-ER Interactions Define a Cellular Energy Landscape to Guide Cargo Transport

The paper analyzes EGFR-endosome transport dynamics in living cells, revealing spatially regulated 2-state motion and proposing an ER-driven free-energy landscape model for cargo transport.

Mitochondrial GTP Metabolism Regulates Reproductive Aging

This study shows that mitochondrial GTP metabolism regulates reproductive aging in C. elegans by controlling mitochondrial dynamics and homeostasis.

A hierarchical strategy to decipher protein dynamics in vivo with chemical cross-linking mass spectrometry

This paper introduces a hierarchical strategy using CXMS and AlphaFold2 to analyze protein dynamics in vivo, focusing on IDPs and multi-domain proteins.

A Novel ARNT-Dependent HIF-2α Signaling as a Protective Mechanism for Cardiac Microvascular Barrier Integrity and Heart Function Post-Myocardial Infarction

This study identifies HIF2/ARNT as a protective axis in cardiac endothelial cells post-MI, preventing vascular leakage and inflammation through suppression of IL6.

Cryo-EM of α-tubulin isotype containing microtubules revealed a contracted structure of α4A/β2A microtubules

The paper determines cryo-EM structures of microtubules composed of different α-tubulin isotypes and finds that α4A/β2A microtubules show longitudinal contraction compared to other isotype combinations.

Aberration modeling in deep learning for volumetric reconstruction of light-field microscopy

This paper introduces AM-VCD, a deep learning network that corrects spherical aberration in light-field microscopy to enable high-speed 3D imaging with uniform resolution.

Prion-like characteristics of Hepatitis E virus ORF3 protein are associated with virus release and pathogenesis

This study identifies HEV-ORF3 as a prion-like protein that facilitates virion release and pathogenesis by forming filamentous structures, highlighting its role in viral assembly.