Author

Y.-S. Huoh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Assay:DNA methylation· 1

Frequent Co-Authors

S. Hur· 2 shared B. Wu· 1 shared D. Mathis· 1 shared D. Yang· 1 shared E. Greenwald· 1 shared H. Arthanari· 1 shared K. Bansal· 1 shared Q. Zhang· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCell Biology

S. Hur

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2 papers

Recent·Most cited

Mechanism for controlled assembly of transcriptional condensates by Aire

Y.-S. Huoh, Q. Zhang, R. Torner, S. C. Baca, H. Arthanari, S. Hur

This paper identifies a multi-layered mechanism by which Aire forms transcriptional condensates on enhancers through coordinated interactions between its CARD, PHD1, and CTT domains.

bioRxiv · Oct 23, 2023Cell Biology

Dual functions of Aire CARD multimerization in the transcriptional regulation of T cell tolerance

Y.-S. Huoh, B. Wu, S. Park, D. Yang, K. Bansal, E. Greenwald, W. P. Wong, D. Mathis, S. Hur

This study shows that Aire's CARD-mediated multimerization forms nuclear foci and affects transcriptional activity, but also increases susceptibility to PML body interactions, which can impair its function.

bioRxiv · Feb 26, 2020Immunology