Author

S. Hur

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:cell signaling & trafficking· 5 Research Focus:chromatin & epigenetic regulation· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 3 Assay:proteomics· 3 Approach:biophysical modeling· 2 Research Focus:cell type annotation· 2

Frequent Co-Authors

S. Ahmad· 3 shared S. Park· 3 shared C. Benoist· 2 shared C. Cadena· 2 shared F. Leng· 2 shared Q. Zhang· 2 shared W. Zhang· 2 shared X. Mu· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersImmunology

S. Ahmad

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Mechanism for controlled assembly of transcriptional condensates by Aire

Y.-S. Huoh, Q. Zhang, R. Torner, S. C. Baca, H. Arthanari, S. Hur

This paper identifies a multi-layered mechanism by which Aire forms transcriptional condensates on enhancers through coordinated interactions between its CARD, PHD1, and CTT domains.

bioRxiv · Oct 23, 2023Cell Biology

FoxP3 recognizes microsatellites and bridges DNA through multimerization

W. Zhang, F. Leng, X. Wang, R. N. Ramirez, J. Park, C. Benoist, S. Hur

This study shows FoxP3 forms multimers to bridge DNA through TnG repeats, revealing a new DNA recognition mechanism involving microsatellites.

bioRxiv · Jul 12, 2023Biochemistry

FoxP3 can fold into two distinct dimerization states with divergent functional implications for T cell homeostasis

F. Leng, W. Zhang, R. Ramirez, J. Leon, Y. Zhong, J. van der Veeken, A. Rudensk, C. Benoist, S. Hur

This study shows FoxP3 can form two dimerization states, with head-to-head dimerization supporting function and swap-dimerization impairing it.

bioRxiv · Feb 8, 2022 · PreprintImmunology

Stress granules are shock absorbers that prevent excessive innate immune responses to dsRNA

S. Hur, M. Paget, C. Cadena, S. Ahmad, H. Wang, T. Jordan, E. Kim, Q. Zhang, B. Koo, S. Lyons, P. Ivanov, B. tenOever, X. Mu

This study shows stress granules regulate immune responses to dsRNA by preventing excessive inflammation and viral replication.

bioRxiv · Apr 26, 2021Immunology

Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases

K. Kato, S. Ahmad, Z. Zhu, J. Young, X. Mu, S. Park, H. Malik, s. Hur

The paper reveals conserved interaction rules between RNA helicases and TRIM E3 ligases in vertebrate innate immunity using cryo-EM and biochemistry.

bioRxiv · Aug 26, 2020Biochemistry

Dual functions of Aire CARD multimerization in the transcriptional regulation of T cell tolerance

Y.-S. Huoh, B. Wu, S. Park, D. Yang, K. Bansal, E. Greenwald, W. P. Wong, D. Mathis, S. Hur

This study shows that Aire's CARD-mediated multimerization forms nuclear foci and affects transcriptional activity, but also increases susceptibility to PML body interactions, which can impair its function.

bioRxiv · Feb 26, 2020Immunology

Ubiquitin-dependent and -independent roles of E3 ligase RIPLET in innate immunity

C. Cadena, S. Ahmad, A. Xavier, J. Willemsen, S. Park, J. W. Park, S.-W. Oh, T. Fujita, F. Hou, M. Binder, S. Hur

RIPLET functions as a molecular glue to assemble signaling scaffolds for the antiviral innate immune receptor RIG-I.

bioRxiv · Mar 7, 2019Immunology