Combining an autoactivated cGAS mutant with membrane-tethered IL-12 via mRNA lipid nanoparticles promotes systemic tumor control
Anli Zhang, Yan Fang, Ruoshi Peng, Minglu Yan, Zihang Chen, Tuo Li, Jiaxing Tan, Li Sun, Zhijian J. Chen
This paper combines an autoactivated cGAS mutant with membrane-tethered IL-12 via mRNA LNPs to promote systemic tumor control in mouse models.
bioRxiv · Oct 16, 2026 · PreprintCancer Biology