Tuo Li

This paper combines an autoactivated cGAS mutant with membrane-tethered IL-12 via mRNA LNPs to promote systemic tumor control in mouse models.

This paper shows that disrupting a faulty splice donor site in progeria reduces toxic protein levels and extends lifespan in mice.

This study shows that the cGAS-STING pathway suppresses ecDNA-driven tumorigenesis by detecting ecDNA fragments and restricting their formation.

This study identifies PtdIns(3,5)P2 as an endogenous ligand of STING that cooperates with cGAMP to activate innate immune signaling.

This study shows ecDNA-driven oncogene super-expressors create an immunoevasive tumor microenvironment in PDAC by promoting myCAF expansion and suppressing T cell infiltration.