Anli Zhang

Combining an autoactivated cGAS mutant with membrane-tethered IL-12 via mRNA lipid nanoparticles promotes systemic tumor control

This paper combines an autoactivated cGAS mutant with membrane-tethered IL-12 via mRNA LNPs to promote systemic tumor control in mouse models.

Innate immune sensing via the cGAS-STING pathway restricts extrachromosomal DNA-driven tumorigenesis

This study shows that the cGAS-STING pathway suppresses ecDNA-driven tumorigenesis by detecting ecDNA fragments and restricting their formation.