Spatial cholesterol homeostasis gatekeeps T-cell development and activation by orchestrating signaling and fitness
Yanchi Li, Xing He, Chenxi Li, Zhengxu Ren, Jing Huang, Qian Yang, Mingming Gao, Yingjie Wu, Xiwei Liu, Chenqi Xu
This study identifies OSBP as essential for ER-to-PM cholesterol transport in T cells, linking cholesterol spatial distribution to TCR signaling and T-cell development.
bioRxiv · Aug 20, 2026 · PreprintImmunology