Author

Zhengxu Ren

Center for Excellence in Molecular Cell Science

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Approach:deep learning· 1

Frequent Co-Authors

Chenqi XuiD· 3 shared Xiwei LiuiD· 2 shared Anhui Wang· 1 shared Bo SuniD· 1 shared Chenxi Li· 1 shared Dinglin ZhangiD· 1 shared Fei ShaoiD· 1 shared Guohui LiiD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersImmunology

Chenqi XuORCID

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3 papers

Recent·Most cited

Spatial cholesterol homeostasis gatekeeps T-cell development and activation by orchestrating signaling and fitness

Yanchi Li, Xing He, Chenxi Li, Zhengxu Ren, Jing Huang, Qian Yang, Mingming Gao, Yingjie Wu, Xiwei Liu, Chenqi Xu

This study identifies OSBP as essential for ER-to-PM cholesterol transport in T cells, linking cholesterol spatial distribution to TCR signaling and T-cell development.

bioRxiv · Aug 20, 2026 · PreprintImmunology

Modular counterplays shape condensation and signaling of chimeric antigen receptor

Yiran Jiang, Zhengxu Ren, Jijun Luo, Haochen Yang, Xiwei Liu, Hui Chen, Chenqi Xu, Jizhong Lou

This study shows that PD-1 disrupts CAR-LCK condensates by binding CAR, and adding a CD3ε module stabilizes these condensates, enhancing CAR T cell activity against solid tumors.

bioRxiv · Jul 30, 2026 · PreprintImmunology

Catch-bond engineering surpasses high-affinity maturation for T cell receptor therapies against solid tumors

Tianqi Huang, Runyu Wang, Dinglin Zhang, Siqi Wu, Yuanhao Wang, Yuanhao Wang, Zhengxu Ren, Sifan Wang, Lan Li, Yan Zhou, Xiaojing Wang, Yanling Bao, Mingyu Fan, Luxue Zhang, Junshuang Liu, , Xiang Zhao

This study shows that catch-bond engineering improves TCR-T cell therapy efficacy against solid tumors without off-target toxicity, surpassing traditional high-affinity maturation strategies.

bioRxiv · Jul 29, 2026 · PreprintImmunology