Jing Huang

The virulence and motility of Pseudomonas syringae pv. Actinidiae mediated by a temperature sensor HktS-HktR

This study identifies HktS-HktR as a temperature sensor in Psa that regulates virulence and motility by controlling T3SS expression and bacterial movement.

Spatial cholesterol homeostasis gatekeeps T-cell development and activation by orchestrating signaling and fitness

This study identifies OSBP as essential for ER-to-PM cholesterol transport in T cells, linking cholesterol spatial distribution to TCR signaling and T-cell development.

Distinct CD8+ T-cell types Associated with COVID-19 Severity in Unvaccinated HLA-A2+ Patients

The paper identifies distinct CD8+ T-cell types associated with mild versus severe COVID-19 in unvaccinated HLA-A2+ patients, showing protective immunity correlates with specific cell subsets.

Blockade of Tim-3 pathway in a mouse model of Toxoplasmosis: impact on brain leukocyte infiltration, parasite burden, and neuroinflammation

This study shows that blocking the Tim-3 pathway in a mouse Toxoplasma gondii infection model reduces parasite burden and increases immune response markers.

Histone H2BK120 ubiquitination modulates PRC1 activity and H2AK119ub deposition on nucleosomes

The paper reveals how H2BK120ub enhances PRC1 activity and modulates H2AK119ub deposition, linking active and repressive histone modifications in gene regulation.

MEGSA: A powerful and flexible framework for analyzing mutual exclusivity of tumor mutations

The paper introduces MEGSA, a framework for analyzing mutual exclusivity of tumor mutations, identifying novel gene sets and associations in cancer types like AML and breast cancer.