ImmunologybioRxivPreprint
Spatial cholesterol homeostasis gatekeeps T-cell development and activation by orchestrating signaling and fitness
Yanchi Li, Xing He, Chenxi Li…·Chenqi Xu
This study identifies OSBP as essential for ER-to-PM cholesterol transport in T cells, linking cholesterol spatial distribution to TCR signaling and T-cell development.
DOI 10.64898/2026.08.16.745088