Chenqi Xu

Spatial cholesterol homeostasis gatekeeps T-cell development and activation by orchestrating signaling and fitness

This study identifies OSBP as essential for ER-to-PM cholesterol transport in T cells, linking cholesterol spatial distribution to TCR signaling and T-cell development.

Modular counterplays shape condensation and signaling of chimeric antigen receptor

This study shows that PD-1 disrupts CAR-LCK condensates by binding CAR, and adding a CD3ε module stabilizes these condensates, enhancing CAR T cell activity against solid tumors.

Catch-bond engineering surpasses high-affinity maturation for T cell receptor therapies against solid tumors

This study shows that catch-bond engineering improves TCR-T cell therapy efficacy against solid tumors without off-target toxicity, surpassing traditional high-affinity maturation strategies.

Cholesterol esterification blockade boosts immunotherapy and reduces liver cancer relapse

This study identifies SOAT1 as a target for improving immunotherapy and reducing liver cancer relapse by blocking cholesterol esterification.