U1 AMO (antisense morpholino oligos) disrupts U1 snRNP structure to promote intronic PCPA (premature cleavage and polyadenylation)
Qiumin Feng, Zejin Lin, Yanhui Deng, Yi Ran, Andy Peng Xiang, Congting Ye, Chengguo Yao
The paper shows that U1 AMO disrupts U1 snRNP structure, leading to intronic premature cleavage and polyadenylation by affecting RNAPII interaction and transcription elongation.
bioRxiv · Feb 24, 2023 · PreprintMolecular Biology