Andy Peng Xiang

This study identifies Cd34+/Sox4+ mesenchymal cells in the murine testicular interstitium as potential Leydig cell progenitors through single-cell transcriptomic analysis.

The paper develops a model of human spine and spinal cord development using hPSC-derived neuromesodermal progenitors and identifies a new cell population involved in trunk development.

The paper shows that U1 AMO disrupts U1 snRNP structure, leading to intronic premature cleavage and polyadenylation by affecting RNAPII interaction and transcription elongation.

This study uses single-cell RNA sequencing to analyze testicular aging in humans, identifying molecular mechanisms and potential therapeutic targets for age-related male fertility decline.

This study shows that AAV-mediated gene therapy can restore testosterone production and fertility in a mouse model of Leydig cell failure.

This study creates a single-cell and single-nucleus transcriptomic atlas of human skeletal muscle ageing, revealing mechanisms in muscle stem cells, myofibers, and the microenvironment.

This study shows that CFIm25 regulates human stem cell function through effects on RNA polymerase II occupancy and gene expression, independent of its role in mRNA polyadenylation.