Selective GRAB sensors reveal distinct endocannabinoid dynamics in vivo
Ruyi Cai, Yueqi Yang, Shangxuan Cai, Ana Isabel Silva de Sousa, Kathryn L. Todd, Lei Wang, WeiJian Teo, Ao Dong, Shuaiyu Chen, Hui Dong, Huan Wang, Zhaofa Wu, Yanling Qiao, Peng Xu, Chen Song, , Yulong Li
The paper develops selective fluorescent sensors to detect endocannabinoid dynamics in vivo and shows that Δ9-THC induces sustained 2-AG signaling in the nucleus accumbens.
bioRxiv · Aug 12, 2026 · PreprintNeuroscience