Ao Dong

The paper develops selective fluorescent sensors to detect endocannabinoid dynamics in vivo and shows that Δ9-THC induces sustained 2-AG signaling in the nucleus accumbens.

The paper develops a genetically encoded adenosine sensor to show activity-dependent non-vesicular adenosine release from somatodendritic regions via calcium influx and equilibrative transporters.

This study shows that deficiency in DAGLB, an endocannabinoid synthase, contributes to Parkinson's disease by impairing dopaminergic neuron function and motor learning, with potential therapeutic implications for 2-AG augmentation.

This study investigates the mechanisms of 2-AG mobilization in the dorsal lateral striatum following synaptic stimulation, revealing the roles of glutamatergic and cholinergic neurotransmission.

The paper introduces a genetically encoded fluorescent sensor, GRABeCB2.0, to measure endocannabinoid dynamics with high spatiotemporal resolution in vitro and in vivo, revealing new insights into eCB signaling in neurons and brain regions.

The paper identifies synucleins as essential for vesicular exocytosis of endocannabinoids, linking their role in Parkinson's Disease to synaptic plasticity.

The paper develops GRABNE sensors for rapid, specific in vivo detection of norepinephrine, demonstrating their use in various experimental contexts.

PARIS is an optogenetic tool that enables high-resolution mapping of functional gap junctions in cultured cells and Drosophila neurons.