Author

Yannan Qu

Westlake University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioinformatics· 1 Molecular Biology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:protein design· 3 Approach:deep learning· 2 Approach:experimental assay· 2 Assay:protein structure· 2 Research Focus:benchmarking· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Chentong WangiD· 2 shared Dongliang LiuiD· 2 shared Hongli ZhuiD· 2 shared Huaizong SheniD· 2 shared Longxing CaoiD· 2 shared Zijie ZhengiD· 2 shared Dachuan CheniD· 1 shared Deng PaniD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersSynthetic Biology

Chentong WangORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

De novo design of metalloproteases for targeted amyloid-β cleavage

Yannan Qu, Chentong Wang, Hongli Zhu, Yanjun Wang, Longxing Cao

This paper designs metalloproteases that specifically cleave targeted peptide bonds in amyloid-β using a generative model, achieving high specificity and catalytic efficiency.

Vita · Jan 1, 2026Peer-reviewedSynthetic Biology

AtKC1 inhibits AtAKT1 activation via its amino-terminal inhibitory domain

Zijie Zheng, Yannan Qu, Jiexin Chen, Yuyue Tang, Dongliang Liu, Zhuo Huang, Huaizong Shen

The paper identifies an inhibitory domain in AtKC1 that stabilizes the closed conformation of AKT1, preventing its activation, and shows a stoichiometry change in a mutant form.

Plant Communications · Feb 19, 2025Peer-reviewedBiochemistry

Proteus: exploring protein structure generation for enhanced designability and efficiency

Chentong Wang, Yannan Qu, Zhangzhi Peng, Yukai Wang, Hongli Zhu, Dachuan Chen, Longxing Cao

Proteus generates protein backbones efficiently without pre-training, showing high designability in in silico and experimental tests.

bioRxiv · Feb 10, 2024 · PreprintBioinformatics

Structure and engineering of miniature Acidibacillus sulfuroxidans Cas12f1

Zhaowei Wu, Dongliang Liu, Deng Pan, Haopeng Yu, Jin Fa Shi, Jiacheng Ma, Wenhan Fu, Zhipeng Wang, Zijie Zheng, Yannan Qu, Fan Li, Weizhong Chen, Xingxu Huang, Huaizong Shen, Quanjiang Ji

The paper reports the structure of AsCas12f1 and engineers it to enhance genome editing activity in human cells.

bioRxiv · Jul 3, 2023 · PreprintMolecular Biology