Huaizong Shen

The paper introduces a foundation model and automated pipeline for cryo-EM image processing, improving efficiency and quality assessment in structural biology.

The paper introduces SaprotHub, a platform that simplifies training and sharing of protein language models, enabling non-experts to build and collaborate on customized models.

This study determines the closed and open structures of human XPR1, revealing its phosphate export mechanism and potential therapeutic implications.

The paper identifies an inhibitory domain in AtKC1 that stabilizes the closed conformation of AKT1, preventing its activation, and shows a stoichiometry change in a mutant form.

The paper reports the structure of AsCas12f1 and engineers it to enhance genome editing activity in human cells.