Damage sensing recruitment of a lipid phosphatase couples lysosomal membrane repair to proteostatic adaptation
Yanwei Su, João Mello-Vieira, Dmytro Puchkov, Gillian L. Dornan, Max Ruwolt, Elisabeth Südhoff, Oluwatobi Andrew Adeosun, Heike Vogel, Simon Sündermann, Annette Schürmann, Joost C. M. Holthuis, Fan Liu, Ivan Đikić, Michael Ebner, Volker Haucke
This study shows MTMR14 is recruited to damaged lysosomes to remodel lipids, reduce mTORC1 signaling, and support proteostasis during lysosomal injury.
bioRxiv · Apr 5, 2026 · PreprintCell Biology