Psoriasis-related neuroinflammation disrupts thalamostriatal signalling driving anhedonia in both humans and mice
Deepika Sharma, Lilya Andrianova, Rhona McGonigal, Kirstyn Gardner-Stephen, Hassan al Fadhel, Flavia Sunzini, Kristian Stefanov, Dominique L Chaput, Jennifer A. Barrie, Richard Hohne, Megan Saathoff, Yaprak Karabalci, Alfredo E. Montes-Gómez, Julie-Myrtille Bourgognon, Ana González-Rueda, , Jonathan Cavanagh
This study identifies thalamostriatal circuit disruption as a conserved neuroinflammatory mechanism linking systemic inflammation to depression and anhedonia in humans and mice.
bioRxiv · Jun 26, 2024 · PreprintNeuroscience