Author

Megan Saathoff

University of Glasgow

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:gene regulatory network inference· 1 Assay:imaging· 1

Frequent Co-Authors

Deepika SharmaiD· 2 shared Jennifer A. BarrieiD· 2 shared John J ColeiD· 2 shared Jonathan CavanaghiD· 2 shared Kirstyn Gardner-StepheniD· 2 shared Lilya AndrianovaiD· 2 shared Michael T. CraigiD· 2 shared Rhona McGonigaliD· 2 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Deepika SharmaORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Neuroinflammation driven by TLR7 activation in mice results in a global inflammatory response driving circuit-specific changes in neuronal gene expression

Kirstyn Gardner-Stephen, Robin J Carvajal-Quisilema, Lilya Andrianova, Rhona McGonigal, Deepika Sharma, Jennifer A. Barrie, Megan Saathoff, John J Cole, Nigel Balfour Jamieson, Michael T. Craig, Jonathan Cavanagh

This study investigates neuroinflammation in mice driven by TLR7 activation, finding global immune activation and region-specific neuronal gene expression changes in mood-related brain areas.

bioRxiv · Apr 25, 2025 · PreprintNeuroscience

Psoriasis-related neuroinflammation disrupts thalamostriatal signalling driving anhedonia in both humans and mice

Deepika Sharma, Lilya Andrianova, Rhona McGonigal, Kirstyn Gardner-Stephen, Hassan al Fadhel, Flavia Sunzini, Kristian Stefanov, Dominique L Chaput, Jennifer A. Barrie, Richard Hohne, Megan Saathoff, Yaprak Karabalci, Alfredo E. Montes-Gómez, Julie-Myrtille Bourgognon, Ana González-Rueda, , Jonathan Cavanagh

This study identifies thalamostriatal circuit disruption as a conserved neuroinflammatory mechanism linking systemic inflammation to depression and anhedonia in humans and mice.

bioRxiv · Jun 26, 2024 · PreprintNeuroscience

SARS-CoV-2's evolutionary capacity is mostly driven by host antiviral molecules

Kieran D. Lamb, Martha M. Luka, Megan Saathoff, Richard J Orton, My V. T. Phan, Matthew L. Cotten, Ke Yuan, David L. Robertson

The paper uses machine learning to identify mutational signatures in SARS-CoV-2 genomes and links them to host antiviral molecules, showing these drive most of the virus's evolutionary changes.

bioRxiv · Apr 7, 2023 · PreprintGenomics