Gauthier Dangla-Pélissier

The paper compares binding modes and thermodynamic properties of single domain and double domain antibodies using an integrated interface model.

This paper demonstrates the use of TfR1-targeting single-domain antibodies to deliver siRNAs systemically to deep brain regions, achieving efficient knockdown at low doses.

This study identifies cross-species reactive VHHs targeting a novel TfR1 epitope, enabling efficient BBB crossing for CNS drug delivery.